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Association between duration of phenoxybenzamine use and postoperative delirium in suspected adrenal pheochromocytoma: a retrospective cohort study

  • 0Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Medicine +

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November 21, 2024

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November 21, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Prolonged phenoxybenzamine use increases the risk of postoperative delirium, particularly in patients without pheochromocytoma. This finding is independent of other risk factors, emphasizing appropriate drug duration for patient safety.

Area Of Science

  • Anesthesiology
  • Pharmacology
  • Surgical Oncology

Background

  • Limited evidence exists on the link between phenoxybenzamine duration and postoperative delirium in suspected adrenal pheochromocytoma.
  • Phenoxybenzamine is a critical medication for managing pheochromocytoma, but its optimal duration requires further investigation regarding patient outcomes.

Purpose Of The Study

  • To investigate the association between phenoxybenzamine use duration and the incidence of postoperative delirium.
  • To explore potential interactions between phenoxybenzamine duration and other variables influencing postoperative delirium.

Main Methods

  • Retrospective cohort study of 527 patients with suspected pheochromocytoma.
  • Data collected included CT characteristics, preoperative preparation, intraoperative details, and outcomes.
  • Logistic regression and interaction effect analyses were employed.

Main Results

  • Postoperative delirium occurred in 20.5% of participants (18.0% in pheochromocytoma group, 22.0% in non-pheochromocytoma group).
  • Increased phenoxybenzamine duration was positively associated with a higher risk of postoperative delirium (OR=1.05, p<0.01).
  • An interaction effect was observed, indicating the relationship between phenoxybenzamine duration and delirium varied based on pheochromocytoma status (p<0.05).

Conclusions

  • Inappropriate phenoxybenzamine duration is an independent risk factor for postoperative delirium.
  • The risk of delirium increases with longer phenoxybenzamine use, especially in patients without pheochromocytoma.
  • Optimizing phenoxybenzamine treatment duration is crucial for reducing postoperative delirium incidence.

Keywords:

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