The link between BDNF and platelets in neurological disorders
Nezha Bouhaddou1, Meryem Mabrouk2, Farah Atifi2
1Physiology and Physiopathology Team, Genomics of Human Pathologies Research Center, Faculty of Sciences, Mohammed V University, Rabat, Morocco.
Heliyon
|November 21, 2024
Summary
Platelets store Brain-Derived Neurotrophic Factor (BDNF), crucial for neurological repair. This review explores BDNF release from platelets and its connection to neurological disorders.
Area of Science:
- Neuroscience
- Hematology
- Biochemistry
Background:
- Platelets are significant reservoirs of growth and neurotrophic factors.
- Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin found in both the brain and platelets.
- Platelet-derived BDNF's role in vascular repair and neurological health is under investigation.
Purpose of the Study:
- To review the relationship between BDNF and platelets.
- To explore factors influencing BDNF release from platelets into circulation.
- To investigate the impact of anti-platelet drugs on BDNF secretion.
Main Methods:
- Literature review of studies on BDNF, platelets, and neurological disorders.
- Analysis of existing research on neurotrophic factor release mechanisms.
- Synthesis of data regarding the effects of anti-platelet therapies on BDNF levels.
Main Results:
- Platelets are a major source of circulating BDNF.
- Several factors may modulate platelet BDNF release, though not fully elucidated.
- The effect of common anti-platelet medications on BDNF secretion requires further study.
Conclusions:
- Platelet BDNF plays a potential role in neurological health and disease.
- Understanding BDNF release mechanisms is critical for therapeutic strategies.
- Further research is needed to clarify the clinical implications of platelet BDNF and anti-platelet drug interactions.
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