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Chronic Inflammation and Age-Related Hearing: Based on Mendelian Randomization
Yan Wang1,2,3,4, He Zhao2,3,4, Kun Zhao1,2,3,4
1The Second Medical College, Binzhou Medical University, Yantai, Shandong, People's Republic of China.
Journal of Inflammation Research
|November 21, 2024
Summary
Chronic inflammation is linked to age-related hearing loss (ARHL), with inflammatory factors accumulating in auditory centers. However, genetic factors for chronic inflammation do not increase ARHL risk.
Area of Science:
- Otolaryngology
- Immunology
- Gerontology
Background:
- Age-related hearing loss (ARHL) involves auditory system pathologies and is closely linked to chronic inflammation.
- The causal relationship between chronic inflammation and ARHL requires further in-depth investigation.
Purpose of the Study:
- To investigate the causal relationship between chronic inflammation and ARHL.
- To examine inflammation changes in the central auditory nervous system in aging mice and elderly individuals with ARHL.
Main Methods:
- Cohort study involving age-appropriate mice and elderly individuals with ARHL.
- Analysis of clinical data, including C-reactive protein (CRP) levels.
- Mendelian randomization to assess causality between chronic inflammation and ARHL.
Main Results:
- Significantly higher CRP levels were observed in the ARHL group compared to the normal group.
- Evidence of chronic inflammation in the auditory centers of individuals with ARHL.
- Mendelian randomization indicated no causal link between genetic chronic inflammation factors and increased ARHL risk.
Conclusions:
- This study provides reliable causal evidence for the association between chronic inflammation and ARHL.
- Inflammatory factor accumulation in auditory centers is confirmed, offering a basis for ARHL prevention and treatment.
- Limitations due to differing research objects necessitate further investigation.
