Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urban particulate matter impairs human epidermal keratinocyte biology via the TRPV1-mitochondrial axis and TRPV1-Notch signaling.

Environmental toxicology and pharmacology·2026
Same author

CXCL6 exacerbates metabolic dysfunction-associated steatohepatitis by suppressing LPIN1-mediated fatty acid oxidation in hepatocytes.

International journal of biological sciences·2026
Same author

Role of Sirtuin 6 in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease.

Current issues in molecular biology·2026
Same author

Automated Installation System for Joint Casing with Circumferential Temperature Control in District Heating Pipelines Using a Heat-Shrinkable PEX Tube.

Polymers·2026
Same author

Novel cilengitide derivatives suppress migration and invasion of temozolomide-resistant glioblastoma cells via MAPK/Akt pathway inhibition.

Journal of neuro-oncology·2026
Same author

The ectopic olfactory receptor OR7A17 regulates the proliferation and differentiation of human epidermal keratinocytes, and ginsenoside Rh3 acts as its antagonist.

Journal of ginseng research·2026

Related Experiment Video

Updated: Jun 7, 2025

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP
06:36

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

Published on: April 9, 2013

21.4K

Polyetheretherketone (PEEK) Into the Future: Lowering Infection Rates in Cranioplasty.

Evan B Hughes1, John Alfarone1, Evan S Chernov1

  • 1Department of Otolaryngology, Head and Neck Surgery, State University of New York Upstate Medical University, Syracuse, USA.

Cureus
|November 21, 2024
PubMed
Summary
This summary is machine-generated.

Integrated and nonintegrated 3D-printed polyetheretherketone (PEEK) cranioplasty implants showed similar surgical site infection rates. However, higher Charlson Comorbidity Index and older age were linked to increased infection risk in cranioplasty patients.

Keywords:
cranial vault deformitycranioplastyimplantsurgerysurgical site infection

More Related Videos

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

7.7K
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.6K

Related Experiment Videos

Last Updated: Jun 7, 2025

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP
06:36

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

Published on: April 9, 2013

21.4K
Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

7.7K
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.6K

Area of Science:

  • Neurosurgery
  • Biomaterials Engineering
  • Medical Device Technology

Background:

  • Surgical site infection (SSI) is a common complication after cranioplasty.
  • 3D-printed polyetheretherketone (PEEK) implants offer customized solutions, available in integrated and nonintegrated forms.
  • Previous studies have not compared infection rates between integrated and nonintegrated 3D-printed cranioplasty implants.

Purpose of the Study:

  • To compare infection risk between integrated and nonintegrated 3D-printed PEEK cranioplasty implants.
  • To evaluate the impact of operating room time and hospital stay on infection risk.
  • To identify patient factors influencing post-cranioplasty infection rates.

Main Methods:

  • Retrospective chart review of 197 patients undergoing cranioplasty (2012-2023).
  • Comparison of postcranioplasty infection rates between integrated and nonintegrated 3D implants.
  • Analysis of antibiotic use, operating time, hospital stay, and comorbidities using bivariate statistics and binary logistic regression.

Main Results:

  • Overall infection rate was 12.2%, exceeding the national average.
  • No significant difference in infection rates was found between integrated and nonintegrated implants.
  • Elevated Charlson Comorbidity Index (CCI) of 3-4 (OR 6.36) and increased age (OR 0.955) were associated with higher infection risk.

Conclusions:

  • Integrated and nonintegrated 3D-printed PEEK implants demonstrate comparable efficacy regarding infection risk.
  • Patient comorbidities (CCI) and age are significant risk factors for post-cranioplasty infection.
  • The study highlights the need to consider patient-specific factors in cranioplasty outcomes, despite implant type.