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Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration
I Deniz Derman1,2, Taino Rivera3, Laura Garriga Cerda4
1Engineering Science and Mechanics Department, Penn State University, University Park, PA, United States of America.
International Journal of Extreme Manufacturing
|November 21, 2024
Summary
Skin bioprinting is revolutionizing dermatological research by fabricating skin tissues with specialized bioinks and techniques. Challenges in vascularization and clinical translation are being addressed for regenerative medicine applications.
Area of Science:
- Biotechnology
- Tissue Engineering
- Regenerative Medicine
Background:
- Skin bioprinting offers a promising avenue for creating functional skin substitutes.
- Current research focuses on advanced biofabrication techniques and bioinks for skin tissue engineering.
Purpose of the Study:
- To provide a comprehensive review of skin bioprinting technologies and applications.
- To critically examine the challenges and future directions in skin bioprinting for clinical translation.
Main Methods:
- Review of extrusion-, droplet-, laser-, and light-based bioprinting methods.
- Analysis of bioinks, hair follicle, sweat gland, and pigmentation bioprinting.
- Investigation of biosensor integration for wound healing monitoring.
Main Results:
- Skin bioprinting techniques have advanced significantly, enabling the fabrication of complex skin structures.
- Challenges include achieving vascularization, ensuring safety, and automating processes for clinical use.
- Biosensor integration shows potential for enhanced wound healing monitoring.
Conclusions:
- Skin bioprinting holds transformative potential for tissue engineering and regenerative medicine.
- Addressing current limitations is crucial for successful clinical translation.
- Further research is needed to optimize automated processes and biosensor integration.
