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Developing a Carotid Pseudoaneurysm Model in Swine.

Karolina Banaskiewicz1, Alexander A Oliver2, Rebecca N Treffalls1

  • 1Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA.

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
|November 21, 2024
PubMed
Summary

A new swine model effectively creates traumatic carotid artery pseudoaneurysms (PSAs), offering a valuable tool for studying and improving treatments for this vascular condition.

Keywords:
carotid pseudoaneurysmcarotid stentingendovascular stentingswine carotid pseudoaneurysmswine model

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Area of Science:

  • Vascular Surgery
  • Animal Modeling
  • Medical Device Development

Background:

  • Traumatic carotid artery pseudoaneurysms (PSAs) are vascular anomalies that can lead to stroke.
  • Current treatments like endovascular stenting may not be optimal for healthy, remodelable vessels.
  • Limitations in existing animal models hinder the development of improved PSA treatments.

Purpose of the Study:

  • To introduce and evaluate a novel swine model for creating and studying carotid artery pseudoaneurysms.
  • To provide a suitable platform for testing new treatment modalities for PSAs.
  • To address the need for better animal models that replicate human vasculature.

Main Methods:

  • Pseudoaneurysms were constructed using bovine dura and attached to bilateral carotid arteries in a swine model.
  • Post-operative radiological follow-up was conducted.
  • Histological analysis was performed at 3 and 10 days post-creation.

Main Results:

  • Successful creation of PSAs in swine without immediate complications.
  • Radiological findings demonstrated well-perfused PSAs with hemodynamically relevant turbulence, mimicking human carotid PSAs.
  • Histological examination confirmed thrombus maturation and secure anastomosis of the PSA sac.

Conclusions:

  • The developed swine model is a replicable, cost-effective, and practical tool for advancing carotid PSA management.
  • This standardized model facilitates research into new therapies and computational modeling for PSAs.
  • It offers a valuable resource for educational initiatives in vascular surgery.