Development and Evaluation Essential Oils Nanoemulgel as Human Skin Sanitizer Using Novel Method

Area of Science:

• Pharmaceutical Sciences
• Dermatology
• Microbiology

Background:

• Rising epidemic diseases necessitate alternatives to alcoholic disinfectants due to side effects.
• Essential oils (EOs) are explored as active antimicrobial agents for skin sanitization.

Purpose of the Study:

• To develop, prepare, and evaluate an alcohol-free nanoemulgel skin sanitizer utilizing essential oils.
• To assess the efficacy and safety of the developed nanoemulgel as a disinfectant.

Main Methods:

• Nanoemulsions were prepared using a microwave-based technique and characterized.
• Nanoemulgels were formulated from selected nanoemulsions and evaluated for physical, chemical, and antimicrobial properties.
• A pseudo-ternary phase plot was used to optimize nanoemulsion composition.

Main Results:

• Formulations exhibited nanosized droplets, homogenous distribution, and acceptable charge.
• Nanoemulgels were clear, homogenous, stable, slightly acidic, and possessed good spreadability and plastic rheological flow.
• The nanoemulgel formulations demonstrated conspicuous antimicrobial activity and were safe for skin application.

Conclusions:

• The developed essential oil-based nanoemulgel is a promising alcohol-free skin sanitizer.
• This product offers a viable alternative to alcoholic disinfectants, meeting the demand for natural alternatives.