[RISK FACTORS FOR EARLY GRAFT LOSS AFTER KIDNEY TRANSPLANTATION - BEILINSON TRANSPLANT CENTER EXPERIENCE]

Yonit Rosen-Krauss ¹, Ruth Rahamimov ², Aviad Gravetz ¹

⁰Department of Transplantation, Rabin Medical Center, Beilinson Hospital, Petach-Tikva, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Harefuah +

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November 21, 2024

View abstract on PubMed

Summary

Kidney graft failure within the first year is a significant concern. Pre-transplant diabetes, ischemic heart disease, and using deceased donors are key risk factors for early graft loss.

Area Of Science

Nephrology
Transplantation Immunology
Clinical Epidemiology

Context

Kidney graft failure within the first year post-transplantation poses a significant challenge.
Understanding early graft loss is crucial for improving patient outcomes and transplantation success rates.

Purpose

To evaluate the incidence of kidney graft failure within the first year after transplantation.
To identify and analyze risk factors associated with early kidney graft loss.

Summary

A study of 1735 kidney transplantations found a 6.5% rate of graft loss within the first year.
Key risk factors identified include recipient age >50, pre-transplant diabetes, ischemic heart disease, repeat transplants, marginal donors, delayed graft function, and acute rejection.
Multivariate analysis highlighted pre-transplant diabetes, ischemic heart disease, deceased donor source, and repeat transplants as significant predictors of early graft failure.

Impact

Findings suggest that improved candidate selection and optimized donor kidney selection and preservation, particularly from deceased donors, can mitigate early graft loss.
This research provides valuable insights for refining clinical protocols to enhance long-term kidney transplant success.