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Updated: Jun 7, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
218
Polygenic Risk Score, Healthy Lifestyle Score, and Colorectal Cancer Risk: A Prospective Cohort Study
Yuefan Shen1, Weiwei Chen1, Chengqu Fu1
1Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Summary
A healthy lifestyle can significantly lower colorectal cancer risk, even for individuals with high genetic predisposition. This research highlights the power of lifestyle choices in cancer prevention.
Area of Science:
- Oncology
- Genetics
- Preventive Medicine
Background:
- Colorectal cancer (CRC) development is influenced by both genetic susceptibility and lifestyle choices.
- The degree to which a healthy lifestyle can mitigate inherited CRC risk is not fully understood.
Purpose of the Study:
- To investigate the interplay between genetic risk and lifestyle factors in colorectal cancer incidence.
- To determine if a healthy lifestyle can offset increased genetic predisposition to CRC.
Main Methods:
- Utilized data from 51,171 participants in the Prostate, Lung, Colorectal, and Ovarian Cancer cohort.
- Developed a polygenic risk score using 205 CRC-associated genetic variants.
- Constructed a healthy lifestyle score based on six modifiable factors.
- Employed Cox regression models to analyze associations between genetic/lifestyle factors and CRC risk.
Main Results:
- High genetic risk was associated with significantly increased CRC risk (HR=1.71 for intermediate, HR=2.52 for high risk).
- An unfavorable lifestyle increased CRC risk by 47% compared to a favorable lifestyle.
- Individuals with high genetic risk and a favorable lifestyle had a 45% lower 10-year CRC risk compared to those with high genetic risk and an unfavorable lifestyle.
Conclusions:
- Adherence to a healthy lifestyle can substantially reduce the impact of genetic predisposition on colorectal cancer risk.
- Modifiable lifestyle factors are crucial for colorectal cancer prevention, offering potential for personalized strategies.
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