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Multifocal meningoencephalitis after vaccination against COVID-19
Shuji Mikami1, Mitsuru Ishii2, Tetsuhiro Yano2
1Department of Diagnostic Pathology, National Hospital Organization Saitama Hospital, Wako, Japan.
Pathology International
|November 21, 2024
Summary
An autopsy revealed SARS-CoV-2 spike protein in the brain and adrenal glands of a patient who died after COVID-19 vaccination. This protein may link vaccination to neurological and cardiac issues.
Area of Science:
- Neuropathology
- Immunohistochemistry
- Cardiology
Background:
- Investigating the potential long-term effects of COVID-19 vaccination.
- Examining the autopsy findings of a patient with neurological decline post-vaccination.
Observation:
- Autopsy revealed acute ischemic changes and T-cell infiltration in the brain, and signs of right heart failure.
- SARS-CoV-2 spike protein, but not nucleocapsid protein, was detected in the brain and endocrine glands.
Findings:
- The presence of spike protein suggests a link to vaccination, not active infection.
- Spike protein in the central nervous system may correlate with ischemic changes.
- Spike protein in endocrine glands might be associated with right heart failure via the renin-angiotensin-aldosterone system.
Implications:
- This case highlights a potential, albeit rare, association between COVID-19 vaccination and specific neuropathological and cardiovascular findings.
- Further research is needed to understand the mechanisms and prevalence of these potential vaccine-related effects.
