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Related Experiment Videos

Selection for increased mutation rates with fertility differences between matings.

K E Holsinger, M W Feldman, L Altenberg

    Genetics
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Fertility-based selection can favor increased mutation rates, unlike viability-based models. This occurs when mating success depends on genotype combinations, impacting genetic evolution.

    Area of Science:

    • Evolutionary genetics
    • Population genetics

    Background:

    • Mutation modification studies typically assume sex-symmetric viability selection.
    • Understanding how different selection types affect genetic systems is crucial.

    Purpose of the Study:

    • To investigate the impact of fertility-based selection on mutation rate evolution.
    • To contrast these findings with existing viability-based models.

    Main Methods:

    • Numerical study of a genetic model.
    • Analysis of selection acting on fertility differences between mated pairs.

    Main Results:

    • Fertility selection can favor increased mutation rates, contrary to viability models.
    • Increased mutation rates are favored when forward/back mutation rates are similar and loci are loosely linked.

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  • Selection favoring increased mutation can occur even if reducible to sex-specific viability differences.

    • Conclusions:

    • The type of selection (fertility vs. viability) significantly influences genetic system evolution.
    • Fertility selection introduces novel evolutionary dynamics for mutation rates.