Related Experiment Video
Updated: Jun 7, 2025

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
Published on: March 4, 2022
[Erythrocyte morphological alterations as predictors of kidney injury severity]
Azucena Cruz-Balbuena1, Leticia Piedras-Reyes1, Juan Carlos Sánchez-Serrano1
1Instituto Mexicano del Seguro Social, Órgano de Operación Administrativa Desconcentrada Estatal Puebla, Hospital General de Zona No. 20. Puebla, Puebla, México.
Background:
Chronic kidney disease (CKD) is characterized by decreased renal function. Detecting and treating CKD in its early stages is essential for prognosis and use of less invasive renal treatments. CKD can manifest with different markers of renal damage. However, few studies evaluate the presence of erythrocyte morphological changes in the peripheral blood of patients with CKD.
Objective:
To evaluate the correlation between erythrocyte morphological changes and KDIGO stage as a predictor of the severity of renal damage.
Material And Methods:
A descriptive, prospective, cross-sectional, and correlational study of patients admitted between March and April 2023. Qualitative variables were reported as frequencies and percentages, and quantitative variables were reported by central tendency and dispersion measures. Finally, Spearman correlation was performed between erythrocyte morphological alterations and the KDIGO stage in patients with CKD.
Results:
A total of 385 patients were included, and the correlation of the number of erythrocyte morphological alterations with the KDIGO stage showed that it is directly proportional in a significant way (Spearman's ρ 0.489, p < 0.0001). It was higher for anisocytosis.
Conclusions:
Erythrocyte morphological alterations in patients with CKD are frequent and could be a predictor of the severity of this disease.
More Related Videos
Related Concept Videos
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Nephrons
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Kidney Structure

