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Roles of cathepsin S expression levels on the prognosis and tumour microenvironment in clear cell renal cell carcinoma

  • 0Department of Nephrology, The First People's Hospital in Jinzhou, Dalian, China.
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November 21, 2024

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November 21, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Cathepsin S (CTSS) is elevated in clear cell renal cell carcinoma (ccRCC) and linked to better prognosis. CTSS shows potential as a prognostic biomarker and therapeutic target in ccRCC.

Area Of Science

  • Oncology
  • Biochemistry
  • Immunology

Background

  • The enzyme cathepsin S (CTSS) is increasingly linked to tumor development.
  • The specific role and molecular functions of CTSS in clear cell renal cell carcinoma (ccRCC) are not well understood.

Purpose Of The Study

  • To investigate the role of CTSS in ccRCC.
  • To evaluate CTSS as a potential prognostic biomarker and therapeutic target in ccRCC.

Main Methods

  • Integrated analysis of TCGA and GEO data for CTSS expression in ccRCC.
  • Kaplan-Meier survival analysis, assessment of clinicopathological features, immune infiltrates, and single-cell sequencing.
  • In vitro validation using qRT-PCR and IHC staining.

Main Results

  • CTSS transcriptomic and proteomic levels were significantly higher in ccRCC tissues compared to para-cancerous tissues.
  • Low CTSS expression correlated with poorer prognosis in ccRCC patients.
  • CTSS expression was strongly associated with immune cell infiltration and detectable in monocytes/macrophages.

Conclusions

  • CTSS shows promise as a prognostic biomarker for ccRCC.
  • CTSS represents a potential novel immune-related therapeutic target for ccRCC.

Keywords:

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