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T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia

Talha Badar1, Keith L Knutson2, James Foran1

  • 1Division of Hematology-Oncology and Bone Marrow Transplant Program, Mayo Clinic, Jacksonville, FL.

Blood Advances
|November 21, 2024
PubMed
Abstract

No abstract available in PubMed .

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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