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Updated: Jun 7, 2025

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Chronic psychological stress induces testicular oxidative stress affecting reproductive behavior in rats
Tianfeng Yang1, Xinye Liu1, Chunyan Kang1
1Institute of Cognitive Neuroscience and Department of Psychology, College of Science, Zhejiang Sci-Tech University, Hangzhou, China.
Abstract:
The inhibitory effect of chronic psychological stress on reproductive behavior is widely recognized since long. However, the biological mechanisms underlying these effects, especially the cellular biology of the testicular cells, have not been fully investigated. This study aimed to investigate the effects of chronic psychological stress on rat reproductive behavior and its correlation with testicular cell damage and oxidative stress. The results showed that chronic psychological stress led to a decline in the preference scores of male rats for female rats and caused damage to the testicular tissue structure. Subcellular structures were particularly affected in the chronic psychological stress rats. Furthermore, the levels of MDA, NO, and NOS in testicular cells substantially increased under chronic psychological stress conditions. In conclusion, male reproductive behavioral disorders induced by chronic psychological stress are potentially linked to oxidative damage in testicular tissue.
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