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Hydrogel design and applications for periodontitis therapy: A review
Qingqing Pan1, Zhihui Zong2, Haibo Li1
1School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.
International Journal of Biological Macromolecules
|November 21, 2024
Summary
Hydrogels show promise for treating periodontitis, a common gum disease. This review details how hydrogel properties and drug delivery innovations advance antibacterial, anti-inflammatory, and bone-regenerating therapies for better oral health.
Area of Science:
- Biomaterials Science
- Periodontology
- Drug Delivery Systems
Background:
- Periodontitis is a widespread oral inflammatory disease causing significant periodontal tissue damage.
- Hydrogels are increasingly recognized for their potential as carriers and regenerative agents in periodontitis treatment.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in hydrogel applications for periodontitis therapy.
- To explore hydrogel design principles and their role in drug delivery for oral health.
Main Methods:
- Review of current literature on hydrogel properties (thermosensitive, self-healing, photo-crosslinkable, adhesive).
- Analysis of innovative drug delivery and release mechanisms in hydrogel-based systems.
- Examination of hydrogels in antibacterial, anti-inflammatory, and osteogenic therapies.
Main Results:
- Hydrogels offer versatile properties for tailored periodontitis treatment.
- Advanced hydrogel systems facilitate effective drug delivery for targeted therapies.
- Synergistic combinations of hydrogel therapies show enhanced therapeutic outcomes.
Conclusions:
- Hydrogels represent a significant advancement in periodontitis management.
- Further research into hydrogel design and application can drive progress in oral regenerative medicine.
- Hydrogel-based strategies hold potential for treating periodontitis and other oral conditions.
