Mapping epilepsy biomarkers: a bibliometric and content analysis

Area of Science:

• Neurology
• Biomarker Research
• Bibliometrics

Background:

• Epilepsy is a complex global neurological disorder requiring advanced diagnostic and therapeutic strategies.
• Biomarker identification is a critical focus area in epilepsy research.
• Significant global research efforts are dedicated to understanding and managing epilepsy.

Purpose of the Study:

• To conduct a bibliometric analysis of epilepsy research from 2000-2023.
• To identify trends in epilepsy research, particularly concerning biomarkers.
• To explore emerging areas and their potential impact on epilepsy diagnosis and treatment.

Main Methods:

• Bibliometric analysis of 1,774 publications (2000-2023).
• Keyword co-occurrence analysis to identify research themes.
• Content analysis to link epilepsy aetiologies with biomarkers.

Main Results:

• Research activity in epilepsy has notably increased, especially in the last decade.
• The US, China, and the UK are leading contributors, with growing potential from Asian countries.
• Research trends show a shift towards neuroinflammatory and genetic biomarkers, alongside AI and epigenetics.
• Specific epilepsy causes are being linked to biomarkers, paving the way for personalized medicine.

Conclusions:

• Current epilepsy research is dynamic, with a clear trend towards biomarker-driven diagnostics and therapeutics.
• Emerging fields like artificial intelligence and epigenetics hold significant promise for future epilepsy research.
• The findings provide valuable insights for guiding future research and developing targeted epilepsy management strategies.