Organophosphorus flame retardants in infant's diets from Beijing, China: Detection and risk assessment

As a group of widely used flame retardants, organophosphate esters (OPEs) and their metabolites, organophosphate diesters (di-OPEs), have been widely detected in various environmental media and human samples. However, the information on dietary exposure to OPEs for lactating infants is still limited. Here, 38 OPEs and 10 di-OPEs were monitored in 110 infant formula samples and 122 breast milk samples collected in Beijing, China. 20 OPEs (median: 49.9 ng/g, 16.5-160 ng/g) and 6 di-OPEs (median: 20.6 ng/g, 12.4-30.5 ng/g) were detected with frequency above 50% in infant formula, while 5 OPEs (median: 6.66 ng/g, 0.0566-221 ng/g) and 3 di-OPEs (median: 18.8 ng/g, 1.39-591 ng/g) had detection frequency above 50% in breast milk samples. For lactating infants, the total estimated daily intake (EDI) of ∑₂₀OPEs (850 ng/kg bw/day) from infant formula was comparable with that of ∑₅OPEs (836 ng/kg bw/day) from breast feeding, while the EDI of ∑₆di-OPEs (333 ng/kg bw/day) from infant formula was significantly lower than that of ∑₃di-OPEs (2456 ng/kg bw/day) from breast feeding. In summary, the results highlighted the risks of OPEs exposure from breast feeding. Further studies are warranted to evaluate the developmental toxicity of direct exposure to di-OPEs.