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Updated: Jun 6, 2025

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Myocardial Performance Index to assess cardiac function in autoimmune connective tissue disease: a systematic review

Rudy Hidayat1,2, Sally Aman Nasution3, Faisal Parlindungan4,2

  • 1Rheumatology Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.

Lupus Science & Medicine
|November 21, 2024
PubMed

Insights

This study found elevated Myocardial Performance Index (MPI) in patients with autoimmune connective tissue diseases (ACTD). MPI may aid in the early detection of cardiac dysfunction in these patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Diagnostics

Background:

  • Autoimmune connective tissue diseases (ACTD) can affect cardiac function.
  • Early detection of cardiac abnormalities in ACTD patients is crucial for management.
  • Myocardial Performance Index (MPI) is a potential echocardiographic marker for cardiac function.

Purpose of the Study:

  • To evaluate cardiac function using MPI in ACTD patients without overt cardiovascular abnormalities.
  • To systematically review and meta-analyze studies assessing MPI in various ACTD.
  • To determine if MPI is elevated in ACTD patients compared to healthy controls.

Main Methods:

  • Systematic literature search of Medline, Google Scholar, Scopus, and Cochrane Library (1995-2023).
  • Included ACTD: rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, Sjögren syndrome.
  • Meta-analysis of MPI using Review Manager V.5.4 after quality assessment with Newcastle-Ottawa Scale.

Main Results:

  • Included 22 studies (19 for quantitative synthesis) covering RA, SSc, SLE, SjD, and mixed connective tissue disorder.
  • Both conventional and tissue Doppler imaging (TDI) MPI values were significantly elevated in ACTD patients versus controls.
  • p < 0.00001 for both conventional (MD=0.11) and TDI MPI (MD=0.06).

Conclusions:

  • Patients with ACTD exhibit elevated MPI values compared to healthy individuals.
  • MPI shows potential for early detection and management of cardiac dysfunction in ACTD.
  • Further research is needed to confirm these findings and their clinical implications.
Abstract

Keywords:
Autoimmune DiseasesCardiovascular DiseasesLupus Erythematosus, SystemicScleroderma, SystemicSjogren's Syndrome

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