[Analysis of risk factors for adverse outcomes in 10,135 patients with gastrointestinal malignancies aged 65 years and over who underwent elective surgery]
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View abstract on PubMed
Summary
This summary is machine-generated.Older patients with gastrointestinal cancers face higher risks of adverse surgical outcomes. Key risk factors include advanced tumor stage (IV), comorbidities, open surgery, and longer operation times.
Area Of Science
- Geriatric Surgery
- Surgical Oncology
- Gastrointestinal Malignancies
Background
- Postoperative adverse events pose significant risks for elderly patients undergoing surgery for gastrointestinal malignancies.
- Identifying specific risk factors is crucial for optimizing surgical selection and patient management in this demographic.
Purpose Of The Study
- To investigate the risk factors associated with postoperative adverse events in older adults (≥65 years) with gastrointestinal cancers.
- To provide data to inform surgical decisions and patient evaluations for this population.
Main Methods
- Observational study of 10,135 patients aged 65+ with gastrointestinal malignancies undergoing elective surgery (2008-2022).
- Analysis of clinical characteristics, surgical factors, and treatment outcomes, including postoperative complications, reoperations, and mortality.
- Multivariate logistic regression to identify independent risk factors for adverse outcomes.
Main Results
- Patients aged over 85 had higher rates of advanced tumor stage and comorbidities.
- Minimally invasive surgery rates decreased with increasing age.
- Advanced tumor stage (IV), comorbidities, open surgery, and operation time >180 minutes were significant risk factors for adverse outcomes.
Conclusions
- Older patients with gastrointestinal tumors and comorbidities, particularly those with stage IV disease undergoing open surgery with prolonged operation times, are at increased risk of adverse outcomes.
- These findings highlight the importance of comprehensive pre-operative assessment and tailored surgical planning for elderly patients.
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