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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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RNA Editing02:23

RNA Editing

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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RNA Stability01:53

RNA Stability

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Updated: Jun 6, 2025

RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
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RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

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EDITORIAL for BJP themed issue "noncoding RNA therapeutics".

Yvan Devaux1, Serena Zacchigna2, Rainer Schulz3

  • 1Cardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.

British Journal of Pharmacology
|November 21, 2024
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs are crucial regulators of gene expression. This article explores their therapeutic potential in various diseases, highlighting recent advancements and future directions in non-coding RNA therapeutics.

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RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
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Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Non-coding RNAs (ncRNAs) play vital roles in gene regulation.
  • Dysregulation of ncRNAs is implicated in numerous human diseases.
  • This themed issue focuses on the therapeutic applications of ncRNAs.

Discussion:

  • Exploring the mechanisms of ncRNA action.
  • Evaluating the potential of ncRNAs as therapeutic targets.
  • Addressing challenges in ncRNA delivery and stability.

Key Insights:

  • ncRNAs offer novel therapeutic strategies.
  • Specific ncRNAs show promise in treating cancer and genetic disorders.
  • Advancements in understanding ncRNA function are driving therapeutic development.

Outlook:

  • Future research directions in ncRNA therapeutics.
  • Potential for personalized medicine approaches using ncRNAs.
  • Clinical translation of ncRNA-based therapies.