Effect of meptazinol on chronic anticoagulant therapy

Six elderly hospitalized patients (four female, two male; mean age 85.3 years) stabilized on warfarin therapy were treated with meptazinol (200 mg four times daily) for 7 days. There was no significant difference from pretreatment levels either in mean warfarin dosage prothrombin index after introduction or withdrawal of meptazinol. These findings provide no evidence for any major interaction between warfarin and meptazinol.