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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Jun 6, 2025

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Antitumor Cream: Transdermal Hydrogel Containing Liposome-Encapsulated Ruthenium Complex for Infrared-Controlled

Yu-Fei Yan1, Xue-Lian Li1, Li-Zhen Zeng1

  • 1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Pharmacy, Yunnan University, East Outer Ring Road, Kunming, 650500, P. R. China.

Advanced Healthcare Materials
|November 22, 2024
PubMed
Summary
This summary is machine-generated.

A novel liposome-encapsulated Ruthenium(II) complex (LipoRu) cream offers a painless, non-invasive treatment for skin cancer by combining photodynamic therapy, photothermal therapy, and chemotherapy for enhanced antitumor effects.

Keywords:
antitumor creamhydrogellipid nanoparticlephototherapyskin cancertransdermal

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Area of Science:

  • Materials Science
  • Oncology
  • Nanotechnology

Background:

  • Skin cancer treatment remains a challenge, necessitating innovative therapeutic strategies.
  • Current treatments can be invasive and cause significant side effects.
  • Developing non-invasive and effective drug delivery systems is crucial for improving patient outcomes.

Purpose of the Study:

  • To develop a transdermal drug delivery cream containing a liposome-encapsulated Ruthenium(II) complex (LipoRu).
  • To investigate the synergistic antitumor effects of photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy using LipoRu.
  • To evaluate the efficacy and biodistribution of LipoRu via different administration routes for skin cancer treatment.

Main Methods:

  • Formulation of LipoRu cream for transdermal delivery.
  • In vitro studies on cellular uptake, drug release kinetics (pH-sensitive, infrared-accelerated), and intracellular localization (nucleus, mitochondria).
  • In vivo studies in tumor-bearing mice comparing intratumoral injection, intravenous injection, and transdermal cream application for biodistribution and therapeutic efficacy.

Main Results:

  • LipoRu demonstrated effective tumor accumulation, cellular uptake, and dual nuclear/mitochondrial localization.
  • The released Ru(II) complex exhibited multiple antitumor mechanisms including enzyme inhibition, PDT, PTT, DNA photodamage, and apoptosis/ferroptosis induction.
  • Transdermal LipoRu cream showed significant therapeutic effects in mice with subcutaneous tumors, comparable to other administration routes.

Conclusions:

  • The LipoRu cream is a promising non-invasive and painless therapeutic strategy for skin cancer.
  • This formulation leverages synergistic multimodal cancer treatment (PDT, PTT, chemotherapy) for enhanced efficacy.
  • LipoRu cream holds potential for treating early-stage, advanced, and superficial solid tumors transdermally.