Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.6K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.6K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.9K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.9K
Bones of the Lower Limb: Femur and Patella01:16

Bones of the Lower Limb: Femur and Patella

9.0K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
9.0K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

12.8K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
12.8K
Bones of the Lower Limb: Tibia and Fibula01:10

Bones of the Lower Limb: Tibia and Fibula

14.2K
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
14.2K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

7.1K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and experimental validation of multi-section directional coupler with arbitrary coupling and high directivity for sub-6 GHz UWB applications.

PloS one·2026
Same author

Morphology, morphometry and bilateral asymmetry of the occipital condyles in a historical human skeletal collection.

Folia morphologica·2026
Same author

Biological Consequences of Declining Human Fertility.

Public health challenges·2026
Same author

Cross-over accessory anterior belly of the digastric muscle: a rare anatomical variant with embryological background.

Folia morphologica·2026
Same author

Berengario da Carpi and the first printed neuroanatomical illustration drawn from nature: a short review and iconographic analysis.

Folia morphologica·2026
Same author

Trifurcation of the sciatic nerve. Short bifurcation of the common fibular nerve in the high gluteal region: a case study.

Folia morphologica·2026
Same journal

Novel right-angled origin and severe tortuosity of the right subclavian artery: a previously unrecognized challenge in transradial access.

Folia morphologica·2026
Same journal

An anatomical variation of the musculocutaneous nerve featuring early bifurcation and a transient common trunk with the median nerve: a case report.

Folia morphologica·2026
Same journal

Levator scapulae muscle variability: pathology or anatomical variant? A narrative review with pragmatic classification and imaging relevance.

Folia morphologica·2026
Same journal

When the unexpected happens: educational reflections on and values of dissection of a cadaver with multiple anatomical variations.

Folia morphologica·2026
Same journal

Comparative morphology and morphometry of the right and left atrial appendages using multidetector computed tomography: an age- and sex-based analysis.

Folia morphologica·2026
Same journal

Anatomical variations of the posterior inferior cerebellar artery.

Folia morphologica·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats
05:34

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats

Published on: May 20, 2019

8.4K

Lower limb interosseous membrane in fetuses.

Katarzyna Siwek1,2, Arthur Saniotis3,4, Małgorzata Suchanecka5

  • 1Department of Human Morphology and Embryology, Division of Anatomy, Wroclaw Medical University, Wrocław, Poland. katarzyna.siwek@umw.edu.pl.

Folia Morphologica
|November 22, 2024
PubMed
Summary
This summary is machine-generated.

The leg interosseous membrane (LIM) has fibers running longitudinally, obliquely, and transversely. This study analyzed fetal LIM structure and found sex-based differences, suggesting potential for upper limb reconstruction.

Keywords:
human fetusesleg interosseous membranesexual dimorphism

More Related Videos

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.5K
Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
06:51

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets

Published on: December 19, 2019

6.5K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats
05:34

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats

Published on: May 20, 2019

8.4K
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.5K
Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
06:51

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets

Published on: December 19, 2019

6.5K

Area of Science:

  • Anatomy
  • Biomedical Engineering
  • Orthopedics

Background:

  • The leg interosseous membrane (LIM) provides stability to the tibia and fibula.
  • It serves as an attachment site for several key lower limb muscles.
  • The LIM's collagen fiber network is crucial for its durability.

Purpose of the Study:

  • To investigate the variability of the fetal leg interosseous membrane (LIM).
  • To analyze the directional arrangement and size of collagen fibers within the fetal LIM.
  • To explore potential applications of the LIM in reconstructive surgery.

Main Methods:

  • Studied 222 human fetuses (117-197 days gestation).
  • Utilized a novel dyeing technique to visualize the LIM's syndesmotic structure.
  • Assessed fiber directions (longitudinal, oblique, transverse) and LIM size.

Main Results:

  • LIM fibers predominantly run in longitudinal, oblique, and transverse directions (60-70% frequency).
  • Significant differences were observed in fiber direction frequencies and LIM size between male and female fetuses.
  • Sexually dimorphic characteristics of the LIM were identified.

Conclusions:

  • The directional and size characteristics of the LIM suggest its potential use in reconstructing the upper limb interosseous membrane.
  • Observed sex-based differences in the LIM support distinct lower limb growth dynamics between sexes.