Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

110
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
110
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.1K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

84
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
84
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

89
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
89
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

62
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
62
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

62
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
62

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enzymatic antioxidants in erythrocytes following heavy metal exposure: possible role in early diagnosis of poisoning.

Bulletin of environmental contamination and toxicology·1997
Same author

The effects of midazolam and flumazenil on psychomotor function.

Journal of clinical anesthesia·1997
Same author

Adverse drug reactions from birth to early childhood.

Pediatric clinics of North America·1997
Same author

Value of radiography in diagnosing complications of cardioverter defibrillators implanted without thoracotomy in 437 patients.

AJR. American journal of roentgenology·1997
Same author

Secondary distal renal tubular acidosis in association with urological abnormalities.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·1997
Same author

Role of preoperative donor-specific transfusion and cyclosporine in haplo-identical living related renal transplant recipients.

Nephron·1997

Related Experiment Video

Updated: Sep 20, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Blood Pressure Variability and Frailty in End-Stage Kidney Disease.

T Zanotto1, T H Mercer, A Gupta

  • 1Tobia Zanotto, Ph.D., Department of Occupational Therapy Education, School of Health Professions, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, United States.

The Journal of Frailty & Aging
|November 22, 2024
PubMed
Summary

High systolic blood pressure variability (BPV) is linked to frailty in hemodialysis patients. Continuous monitoring of BPV may help assess frailty in end-stage kidney disease (ESKD) populations.

Keywords:
Frailtyblood pressurecardiovascular diseasesend-stage kidney disease

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.7K
Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
06:26

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

Published on: September 5, 2025

44

Related Experiment Videos

Last Updated: Sep 20, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.7K
Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
06:26

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

Published on: September 5, 2025

44

Area of Science:

  • Nephrology
  • Geriatrics
  • Cardiovascular Medicine

Background:

  • High blood pressure variability (BPV) predicts cardiovascular events and mortality in end-stage kidney disease (ESKD).
  • BPV is also a marker of aging in older adults.
  • The link between BPV and frailty in ESKD patients is not well understood.

Purpose of the Study:

  • To investigate the association between very short-term BPV and frailty.
  • Focus on patients with ESKD undergoing hemodialysis.

Main Methods:

  • Cross-sectional study involving 69 hemodialysis patients in the UK.
  • Continuous, non-invasive BP monitoring to assess systolic and diastolic BPV components (VLF, LF, HF, PSD, LF/HF ratio).
  • Frailty assessed using the Fried frailty phenotype.

Main Results:

  • 37.7% of participants were classified as frail.
  • Frail participants exhibited significantly higher systolic and diastolic BPV across multiple frequency components (HF, VLF, LF, PSD).
  • Age- and sex-adjusted logistic regression showed systolic VLF-BPV, HF-BPV, and PSD-BPV were associated with increased odds of frailty.

Conclusions:

  • Elevated systolic blood pressure variability is associated with frailty in hemodialysis patients.
  • Continuous, beat-to-beat BPV assessment may aid in frailty evaluation within the ESKD population.