Related Experiment Video
Updated: Jun 6, 2025
Contrast Enhanced Vessel Imaging using MicroCT
Published on: January 27, 2011
Impact of individually tailored contrast medium on vascular attenuation in chest CT: a randomized controlled trial
Mette Karen Henning1,2, Trond Mogens Aaløkken2,3, Anne Catrine Martinsen1,4
1Faculty of Health Sciences, Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway.
Background:
Individually tailored contrast medium (CM) may improve vascular image quality in chest computed tomography (CT).
Purpose:
To evaluate vascular attenuation in chest CT by comparing CM dose calculations using lean body mass (LBM) and body surface area (BSA) with a fixed-dose protocol.
Material And Methods:
Patients referred for contrast-enhanced chest CT were categorized as either normal, muscular, or overweight. Patients were accordingly randomized into three CM dosing protocols: fixed-dose group (n = 87), LBM group (n = 92), and BSA group (n = 93).
Results:
Of the patients, 94% in the fixed-dose group, 99% in the LBM group, and 98% in the BSA group achieved optimal vascular attenuation. In the overweight category, lower attenuation was demonstrated in the fixed-dose group compared to the LBM group (P = 0.032) and the BSA group (P = 0.010). In the fixed-dose group, vascular attenuation showed a negative correlation with total body weight for all body composition categories. In the LBM group, a positive correlation was observed between attenuation and total body weight in the muscular category (P = 0.041), while a negative correlation was noted for the overweight category in the BSA group (P = 0.049).
Conclusion:
Fixed-dose CM protocol exhibited larger variations in vascular attenuation between patients of various body weights and body compositions compared to tailored CM doses based on LBM and BSA.
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