Microbiological activity of cefazedone as compared to cefazolin and cephalothin

In a comparison of the antibacterial activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) as compared to other cephalosporins it can be seen that cefazedone possesses good activity against gram-positive bacteria; as regards activity against Enterobacteriaceae, in particular strains of E. coli, Klebsiella species and Proteus mirabilis, they fall within the spectrum of activity of the substance.