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Updated: Jun 6, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

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P-Wave Duration Is Associated With Aging Patterns in Structural Brain Networks.

Elizabeth Haddad^1,2, William Matloff¹, Gilsoon Park¹

¹Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles CA USA.

Journal of the American Heart Association

|November 22, 2024

Summary

Abnormally short P-wave duration (PWD), a marker of atrial abnormalities, is linked to accelerated brain aging in key networks, even without diagnosed heart disease. This highlights PWD

Keywords:

ECG MRI P‐wave duration brain aging magnetic resonance imaging

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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Published on: June 3, 2020

Area of Science:

Neuroscience
Cardiology
Gerontology

Background:

Impaired cardiac function correlates with cognitive decline and brain aging.
Cardiac arrhythmias and their subclinical markers, like P-wave duration (PWD), are implicated in brain injury and cognitive impairment.
The impact of PWD on brain aging patterns, independent of diagnosed cardiac conditions, remains unclear.

Purpose of the Study:

To investigate the association between abnormal P-wave duration (PWD) and brain aging patterns.
To identify specific brain aging networks influenced by PWD using neuroimaging and ECG data.

Main Methods:

Utilized UK Biobank data, including neuroimaging and electrocardiogram (ECG) recordings.
Applied a novel regional "brain age" methodology to assess brain aging.
Analyzed associations between P-wave duration (PWD) and brain aging across different neural networks.

Main Results:

Short P-wave duration (PWD) was associated with accelerated brain aging.
Accelerated aging was observed in sensorimotor, frontoparietal, ventral attention, and dorsal attention networks.
These associations were evident even in individuals without overt cardiac disease.

Conclusions:

Abnormally short P-wave duration (PWD) is linked to structural brain aging.
Findings underscore the importance of considering PWD in studies of brain aging and cognitive health.
Further research is needed to explore brain-based outcomes associated with short PWD.