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Updated: Jun 6, 2025

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
Published on: May 27, 2016
Implementation of OSL nanoDot dosimetry in different treatment techniques for head and neck cancer
Ingrid M Negrete-Hernandez1, Ivonne B Lozano1, Jesus Roman-Lopez2
1Instituto Politécnico Nacional, Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Unidad Legaria, Av. Legaria 694,11500, Ciudad de México, México.
Abstract:
In recent decades, technological advances have been made in the field of radiotherapy and with it the emergence of new dosimetric systems for their calibration and commissioning, among other uses. Such is the case of the measurement in the build-up region, where there is no charged-particle equilibrium, which is reflected in the increase in surface dose for patient treatments and potential skin toxicities as a secondary effect. This study utilizes optically stimulated dosemeters (nanoDot) and the radiochromic film (EBT3) to measure skin doses in patients with head and neck cancer who received radiotherapy. Accurately depicting 15 patients with different diagnoses from 3 linear accelerators using 3D, intensity modulated radiation therapy, or volumetric arc therapy/RapidArc technology, these results were compared with those calculated in the treatment planning system (TPS) and obtaining a percentage of variation for the EBT3 ranged from 0.30% to 6.15%, while that observed for the nanoDot was from 0.51% to 4.88%. This difference may be attributed to the reproducibility of placement in patients. Therefore, for clinical use, nanoDot dosemeters are a viable alternative for in vivo dosimetry where rapid validation of planning system results is required.
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