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YTHDF3 rs7464 A > G polymorphism increases Chinese neuroblastoma risk: A multiple-center case-control study
Huiran Lin1, Yongping Chen2, Liping Chen1
1Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
IUBMB Life
|November 22, 2024
Summary
Genetic variations in YTHDF3, specifically the rs7464 polymorphism, are linked to neuroblastoma (NB) risk in children. This study highlights rs7464 as a significant factor influencing NB susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Neuroblastoma (NB) is a rare pediatric cancer originating in nerve tissue.
- YTHDF3, involved in RNA m6A modification, plays a role in cancer progression.
- Genetic polymorphisms in YTHDF3 may affect its function and influence cancer risk.
Purpose of the Study:
- To investigate the association between YTHDF3 gene polymorphisms (rs2241753, rs2241754, rs7464) and neuroblastoma susceptibility.
- To evaluate the combined effect of these polymorphisms on NB risk.
Main Methods:
- A multicenter study included 898 NB cases and 1734 controls.
- Genotyping of YTHDF3 polymorphisms was performed using the TaqMan assay.
- Logistic regression analysis was employed to assess the association between polymorphisms and NB risk, calculating odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- The rs2241753 GA genotype was associated with decreased NB risk (OR=0.84).
- The rs7464 GG genotype significantly increased NB risk (OR=1.62 for AA vs. GG, OR=1.66 for AA/AG vs. GG).
- Combined analysis revealed that carrying 1-3 risk genotypes increased NB risk (OR=1.28). The rs7464 polymorphism and combined risk genotypes showed persistent significance across subgroups. An interaction between rs7464 and rs2241754 may dramatically increase NB risk.
Conclusions:
- YTHDF3 rs7464 polymorphism significantly impacts neuroblastoma susceptibility.
- Combined risk genotypes of YTHDF3 polymorphisms are associated with increased NB risk.
- Further validation in larger cohorts is warranted to confirm these findings.
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