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Related Concept Videos

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Updated: Jun 6, 2025

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Emerging round cell sarcomas in children.

Jessica L Davis1, Edmund Cheesman2

  • 1Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, 350 West 11Th Street, Indianapolis, IN, 46202, USA. jld13@iu.edu.

Virchows Archiv : an International Journal of Pathology
|November 22, 2024
PubMed
Summary
This summary is machine-generated.

New molecular testing reveals distinct round cell sarcomas beyond Ewing sarcoma. Identifying these rare tumors, including CIC-rearranged and BCOR-altered sarcomas, is crucial for accurate diagnosis and treatment.

Keywords:
BCORCICEWSR1PediatricRound cellSarcoma

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Ewing sarcoma is a prototypic round cell sarcoma.
  • Distinctive round cell sarcomas with unique signatures are increasingly recognized.
  • Accurate differentiation of these tumors is essential for patient management.

Purpose of the Study:

  • To review emerging distinct round cell sarcomas.
  • To highlight diagnostic clues and molecular hallmarks.
  • To differentiate these from Ewing sarcoma.

Main Methods:

  • Review of recent literature on round cell sarcomas.
  • Analysis of clinical, morphologic, and immunophenotypic features.
  • Focus on genetic alterations including gene fusions and rearrangements.

Main Results:

  • CIC-rearranged sarcoma, BCOR-altered sarcomas, and EWSR1-non-ETS sarcomas are distinct entities.
  • These tumors possess unique clinical, morphologic, and genetic profiles.
  • Specific gene fusions (e.g., EWSR1/FUS::NFATc2, EWSR1::PATZ1) characterize some subtypes.

Conclusions:

  • Advanced testing modalities aid in identifying novel round cell sarcomas.
  • Distinguishing these from Ewing sarcoma is critical for prognostication and treatment.
  • Understanding molecular hallmarks facilitates accurate diagnosis.