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Updated: Jun 6, 2025

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Graft-versus-host disease variety toxic epidermal necrolysis. Case report
Elsa M Zúñiga-Lara1, César M Zambrano-Virgen1, José F Gaytán-Morales2
1Servicio de Pediatría, Hospital Infantil de México Federico Gómez, Instituto Nacional de Salud.
Background:
We present the case of a patient who underwent hematopoietic progenitor cell transplantation from a fully compatible unrelated donor and subsequently developed Grade IV skin graft-versus-host disease (GVHD) resembling toxic epidermal necrolysis (TEN).
Clinical Case:
An 11-year-old female, post-transplantation of hematopoietic progenitor cells from a 100% compatible unrelated donor, developed rash-like skin lesions on the trunk and extremities on day +35. A skin biopsy revealed dermal atrophy, vacuolization of the basal layer, and confluent apoptotic keratinocytes with mononuclear inflammatory cells in the dermoepidermis, confirming the diagnosis of TENlike acute cutaneous GVHD.
Conclusion:
The patient experienced an 80% remission of symptoms following dynamic management of immunosuppressants.
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