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Effect of hepatitis B virus infection on the nutrient composition of human breast milk: A prospective cohort study

Peizhen Zhang1, Huiqi Jian2, Chuo Li1

  • 1Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Food Chemistry
|November 22, 2024
PubMed

There are limited data regarding the impact of Hepatitis B virus (HBV) infection on the composition of human breast milk, and there is no international consensus on the nutritional management of newborns of HBV-positive mothers. We hypothesised that HBV infection can alter the composition of breast milk and that newborns require additional nutritional supplements for healthy growth. We conducted a prospective observational cohort study that recruited 150 pregnant women with HBV infection and matched them with a healthy control group. Multivariate linear regression analysis revealed that glucose and albumin concentrations were increased in the HBV group (av. 4.65 mmol/L and av. 5.66 g/L, respectively), whereas lactoferrin concentrations decreased (av. 537.68 pg/mL). Therefore, additional lactoferrin supplementation may be necessary for newborns delivered to women with HBV infection.

Keywords:
AlbuminGlucoseLactoferrinTrace elementsTriglycerides

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