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Updated: May 5, 2026

Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
A Click-generated chalcone allied triazole sensor for Co (II) with INHIBIT logic gate construction and its
Gurjaspreet Singh1, Swati Devi1, Akshpreet Singh2
1Department of Chemistry, Panjab University, Chandigarh 160014, India.
Abstract:
This article presents the synthesis of chalcone allied 1,2,3-triazole via an aldol-click reaction. The newly synthesized compound chalcogenyl based 1,2,3-triazole (7) selectively detects Co (II) ion over other metal cations by UV-visible photophysical study with the limit of detection value of 1.24 × 10-8 M. Job's plot confirms that compound (7) and the Co (II) metal ion have 1:1 binding stoichiometry. The binding mechanism between Co (II) and sensor was confirmed by using 1H NMR spectroscopy, mass spectrometry and DFT studies. The reversible behaviour of 7 towards Co (II) was used to construct a molecular logic gate. The compound (7) demonstrated good antioxidant activity with an IC50 value of 3.04 µM in comparison to 1.31 µM of DPPḢ. Further, to explore the antioxidant effect of ligand 7, the molecular docking analysis was performed with xanthine oxidase protein and the obtained binding energy was -11.08 kcal/mol.
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