Related Experiment Video

Updated: Jun 6, 2025

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk
05:15

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

1.5K

Role for the F-box proteins in heart diseases

Sa Liu1, Yuanying Yang1, Xingyuan Hou1

  • 1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, China.

Pharmacological Research
|November 22, 2024
PubMed

Insights

Proper protein turnover is crucial for heart health, regulated by F-box proteins (FBPs). This review details cardiac FBPs, their roles, and mechanisms, offering new strategies for treating heart disease.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cardiac homeostasis relies on precise protein turnover, governed by the ubiquitin-proteasome system.
  • F-box proteins (FBPs), a class of E3 ubiquitin ligases, are increasingly implicated in cardiac dysfunction when dysregulated.

Purpose of the Study:

  • To comprehensively review F-box proteins within the cardiac system.
  • To categorize cardiac FBPs and elucidate their physiological and pathological functions.
  • To provide novel insights for preventing and treating heart diseases.

Main Methods:

  • Literature review focusing on F-box proteins in the heart.
  • Classification of F-box proteins based on conserved motifs (FBXO, FBXW, FBXL).
  • Analysis of existing data on the roles and mechanisms of cardiac F-box proteins.

Main Results:

  • Identified and categorized cardiac F-box proteins into FBXO, FBXW, and FBXL families.
  • Detailed the physiological and pathological significance of these proteins in the heart.
  • Elucidated the functional mechanisms underlying FBP involvement in cardiac diseases.

Conclusions:

  • F-box proteins play critical roles in cardiac protein turnover and homeostasis.
  • Dysregulation of specific F-box proteins contributes to the pathogenesis of heart diseases.
  • Understanding cardiac F-box protein functions offers new therapeutic avenues for cardiovascular conditions.

Keywords:
E3 ubiquitin ligasesF-box proteinsHeart diseasesProtein degradationUbiquitination

More Related Videos

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish08:09

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

9.7K
A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo14:34

A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo

Published on: May 6, 2022

3.6K

Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.5K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
316
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
386
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
3
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.3K