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Updated: Jun 6, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
New insights into mechanisms underlying cognitive impairment in chronic kidney disease
Mickaël Bobot1, Stéphane Burtey2
1Centre de Néphrologie et Transplantation Rénale, Hôpital de la Conception, Assistance Publique - Hôpitaux de Marseille, Marseille, France; Aix Marseille Univ, INSERM 1263, INRAE 1260, Centre de Recherche en CardioVasculaire et Nutrition, Marseille, France; Centre Européen de Recherche en Imagerie Médicale, Aix-Marseille University, Marseille, France.
Abstract:
Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. Patients with CKD display an increased permeability of the blood-brain barrier. Zimmermann et al. highlighted the implication of potassium efflux in the microglia and its activation, the activation of the interleukin-1b/interleukin-1R pathway, linked to blood-brain barrier permeability and cognitive impairment in CKD. Along with uremic toxicity, this study provides new solid insights about pathophysiological mechanisms of cognitive impairment in CKD, and potential therapeutic targets.
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