Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebral Hemispheres01:05

Cerebral Hemispheres

299
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
299
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

1.5K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.5K
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

1.6K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
1.6K
Somatosensation01:33

Somatosensation

36.4K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.4K
Sutures of the Skull01:22

Sutures of the Skull

6.3K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Multiscale characterization of the human claustrum from histology to MRI.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Association of Fetal Gene Regulatory Gene Deletions With Poor Cognition in Schizophrenia and Community-Based Samples.

The American journal of psychiatry·2026
Same author

Author Correction: Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life.

Nature neuroscience·2026
Same author

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.

bioRxiv : the preprint server for biology·2026
Same author

The genetic architecture of cortical similarity networks.

Nature communications·2026
Same journal

Chlorinated VSLSs Surpass HCFCs in CFC-11-Equivalent Emissions for Ozone Layer Depletion in China.

Nature communications·2026
Same journal

Author Correction: Charge transfer in triphenylamine-tetrazine covalent organic frameworks for solar-driven hydrogen peroxide production.

Nature communications·2026
Same journal

Vegetation browning patterns under compound soil and atmospheric dryness in northern permafrost ecosystems.

Nature communications·2026
Same journal

Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.

Nature communications·2026
Same journal

Radical-omics reveals the hydrogen-abstraction pathway of isoprene oxidation.

Nature communications·2026
Same journal

Toughening elastomer via sequentially activated multi-pathway energy dissipation.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.0K

Microstructural asymmetry in the human cortex.

Bin Wan1,2,3,4, Amin Saberi5,6,7, Casey Paquola6

  • 1Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. binwan@cbs.mpg.de.

Nature Communications
|November 23, 2024
PubMed
Summary
This summary is machine-generated.

Human cerebral cortex microstructural asymmetry shows layer-specific patterns, varying with age and sex. This asymmetry is heritable and linked to functional and behavioral differences, including language and mental health.

More Related Videos

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

27.8K
High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
08:16

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

Published on: December 30, 2015

15.3K

Related Experiment Videos

Last Updated: Jun 6, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.0K
How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

Published on: January 2, 2012

27.8K
High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
08:16

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

Published on: December 30, 2015

15.3K

Area of Science:

  • Neuroscience
  • Human Brain Anatomy
  • Neuroimaging

Background:

  • The human cerebral cortex exhibits hemispheric asymmetry, but the underlying microstructural basis is not fully understood.
  • Understanding microstructural asymmetry is crucial for comprehending brain function and individual differences.

Purpose of the Study:

  • To investigate layer-specific microstructural asymmetry in the human cerebral cortex.
  • To explore the heritability, developmental influences (age, sex), and functional/behavioral correlates of cortical microstructural asymmetry.

Main Methods:

  • Analysis of layer-specific microstructural asymmetry using post-mortem brain tissue.
  • In vivo imaging using Human Connectome Project (HCP) T1w/T2w data (N=1101).
  • Validation with in vivo magnetization transfer (N=286) and quantitative T1 (N=50) measures.

Main Results:

  • Layer-specific anterior-posterior asymmetry patterns were identified, with anterior regions showing leftward and posterior regions rightward asymmetry.
  • In vivo asymmetry patterns, particularly in layer III, showed strong similarity to post-mortem findings.
  • Microstructural asymmetry was found to be heritable, influenced by age and sex, and correlated with functional asymmetry.
  • Differential associations between language, mental health markers, and microstructural asymmetry axes were observed.

Conclusions:

  • The study reveals significant microstructural asymmetry in the human cerebral cortex across different layers.
  • Cortical microstructural asymmetry is heritable, sex- and age-dependent, and functionally relevant.
  • These findings provide insights into the developmental underpinnings of functional and behavioral divergence in the brain.