Plasminogen Activator Inhibitor-1 in the Pathophysiology of Late Life Depression
L Métivier1,2, D Vivien1,2,3, R Goy1,2
1INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Normandie University, UNICAEN, Caen, France.
International Journal of Geriatric Psychiatry
|November 23, 2024
Summary
Late life depression (LLD) is linked to Plasminogen Activator Inhibitor-1 (PAI-1) levels, a marker of hypofibrinolysis. PAI-1 pathway modulation shows promise for treating LLD and depression.
Area of Science:
- Gerontology
- Psychiatry
- Vascular Biology
Background:
- Late-life depression (LLD) presents unique features, including vascular depression and treatment resistance.
- Plasminogen Activator Inhibitor-1 (PAI-1), a serine protease inhibitor, is affected by aging, vascular damage, and stress responses.
- These factors are implicated in the pathogenesis of LLD.
Purpose of the Study:
- To review the literature on the association between LLD and plasma PAI-1 levels.
- To explore the role of PAI-1 in LLD pathogenesis and treatment resistance.
Main Methods:
- Literature review of studies investigating PAI-1 levels in elderly individuals with LLD.
- Analysis of PAI-1 associations with depressive symptoms and related biological markers.
Main Results:
- Studies show an association between PAI-1 levels and depressive symptoms in LLD, despite heterogeneous findings on PAI-1 level variations.
- Elevated levels of inflammatory markers like interleukins 6 and 8 were observed.
- PAI-1 regulatory loops may influence LLD genesis, senescence, and cell death.
Conclusions:
- PAI-1 pathway disruptions are implicated in LLD pathogenesis and antidepressant treatment resistance.
- PAI-1 may serve as a therapeutic target for LLD and depression.
- Further research into PAI-1's role could inform novel treatment strategies.
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