Related Experiment Video
Updated: Jun 6, 2025

A Protocol for Transcranial Photobiomodulation Therapy in Mice
Published on: November 18, 2018
The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review
Zhixin Zhang1,2,3,4,5,6, Zhiyu Zhang7, Peng Liu8,9,10,11,12,13
1Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, No.28 Fuxing Road, Haidian District, Beijing, 100853, China. zhangzhixin0246@126.com.
Abstract:
Photobiomodulation (PBM) is a safe and effective neurotherapy that modulates cellular pathways by altering cell membrane potentials, leading to beneficial biological effects such as anti-inflammatory and neuroregenerative responses. This review compiles studies from PubMed up to March 2024, investigating the impact of light at wavelengths ranging from 620 to 1270 nm on ion channels. Out of 330 articles screened, 19 met the inclusion criteria. Research indicates that PBM can directly affect various ion channels by influencing neurotransmitter synthesis in neighboring cells, impacting receptors like glutamate and acetylcholine, as well as potassium, sodium channels, and transient receptor potential channels. The diversity of studies hampers a comprehensive meta-analysis for evaluating treatment strategies effectively. This systematic review aims to explore the potential role of optoelectronic signal transduction in PBM, studying the neurobiological mechanisms and therapeutic significance of PBM on ion channels. However, the lack of uniformity in current treatment methods underscores the necessity of establishing standardized and reliable therapeutic approaches.
More Related Videos
Related Concept Videos
Channel Rhodopsins
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Photoreceptors and Visual Pathways
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
G-Protein Gated Ion Channels
Sensory...
Mechanically-gated Ion Channels
Ion Channels
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...

