Consensus Statement: Recommendations on Actionable Biomarker Testing for Thyroid Cancer Management

Area of Science:

• Oncology
• Genetics
• Molecular Diagnostics

Background:

• Thyroid cancer management is evolving with the integration of germline and somatic biomarker testing.
• Current biomarker testing approaches exhibit deficiencies and disparities, leading to inconsistent patient care.
• Actionable biomarkers are key for guiding targeted therapy selection in various thyroid cancer subtypes.

Purpose of the Study:

• To develop consensus biomarker testing algorithms and recommendations for thyroid cancer patients.
• To address gaps and disparities in current thyroid cancer biomarker testing strategies.
• To provide practical guidance for physicians navigating the complexities of biomarker testing for targeted therapies.

Main Methods:

• Convening an expert panel to establish consensus algorithms and recommendations.
• Conducting a review of international guidelines on thyroid cancer biomarker testing.
• Performing a literature review to evaluate evidence supporting actionable biomarkers in thyroid cancer.

Main Results:

• Development of consensus-driven algorithms and recommendations for thyroid cancer biomarker testing.
• Identification of key challenges and gaps in current testing landscapes.
• Emphasis on a multidisciplinary team approach for optimal patient care.

Conclusions:

• The developed algorithms and recommendations aim to assist physicians in thyroid cancer biomarker testing.
• These guidelines balance advanced care with practical feasibility, considering economic and jurisdictional factors.
• Recommendations are therapy-agnostic, ensuring broad applicability across different thyroid cancer types.