Burkitt's lymphoma with multi-organ involvement

Burkitt's lymphoma (BL) is an aggressive and rapidly growing B-cell non-Hodgkin lymphoma (NHL) with high rates of extranodal involvement. Primary gastrointestinal lymphomas represent a rare entity with less than 2 % of small intestinal malignancies.

The patient was a 34-year-old man known case of sickle cell trait, presented with abdominal pain, anorexia, nausea, vomiting, constipation, and weight loss of 5 kg during three weeks. The vital signs were within normal ranges. His physical examination revealed abdominal tenderness on the right lower quadrant. Abdominal CT scan showed severe abdominopelvic ascites with ileocecal mass and nodular thickening of the parietal peritoneum. The patient underwent a cecum mass with peritoneal mass resection and appendectomy. In histopathology, Burkitt's lymphoma with peritoneal, omentum, and appendix involvement was diagnosed. For further evaluation, the patient underwent a bone marrow trephine biopsy that was involved. Finally, the patient was diagnosed with Burkitt's lymphoma with multi-organ involvement.

Patients with sporadic BL often present with advanced-stage disease due to the short doubling time of the tumor. In histopathology, the lymph node architecture effaces completely with starry sky appearance. The GI wall thickening and lumen Stenosis are common in cases with gastrointestinal Lymphoma.

We report a rare case of BL with multi-organs involvement such as cecum, appendix, peritoneum, omentum, and bone marrow. This case report highlights the importance of clinicopathologic correlation in the diagnosis of BL in daily practice.