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Updated: May 11, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Pediatric soft tissue tumors
Pierre Mary1, Clelia Thouement1, Tristan Langlais2
1Pediatric Orthopedics Department, CHU Armand Trousseau, APHP, Sorbonne Université, Paris, France.
Abstract:
The initial approach to soft tissue tumors in children and teenagers is everyone's responsibility. While the vast majority is benign, all practitioners dread missing a malignant lesion. The first step involves taking the patient's history and performing a clinical examination. Useful information can be gained from radiographs, ultrasound imaging and MRI. If there is no diagnosis at this stage, a biopsy (preferably percutaneous) is essential because unplanned excision can have serious consequences in terms of morbidity and even mortality. This should only be undertaken at a specialized facility after careful planning by the surgeon and interventional radiologist. Once the diagnosis has been made, the case should be discussed at a tumor board meeting to benefit from multidisciplinary expertise and input. Surgery is an essential component of the treatment and must be done at the appropriate time, after potential systemic (chemotherapy, targeted therapy) or local treatment (radiation therapy). LEVEL OF EVIDENCE: Expert opinion.

