Regional and interregional functional and structural brain abnormalities in neuropathic pain

Neuropathic pain is a severe form of chronic pain due to a lesion or disease of the somatosensory nervous system. Here we provide an overview of the neuroimaging approaches that can be used to assess brain abnormalities in a chronic pain condition, with particular focus on people with neuropathic pain and then summarize the findings of studies that applied these methodologies to study neuropathic pain. First, we review the most commonly used approaches to examine grey and white matter abnormalities using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) and then review functional neuroimaging techniques to measure regional activity and inter-regional communication using functional MRI, electroencephalography (EEG) and magnetoencephalography (MEG). In neuropathic pain the most prominent structural abnormalities have been found to be in the primary somatosensory cortex, insula, anterior cingulate cortex and thalamus, with differences in volume directionality linked to neuropathic pain symptomology. Functional connectivity findings related to treatment outcome point to a potential clinical utility. Some prominent abnormalities in neuropathic pain identified with EEG and MEG throughout the dynamic pain connectome are slowing of alpha activity and higher regional oscillatory activity in the theta and alpha band, lower low beta and higher high beta band power. Finally, connectivity and coupling findings placed into context how regional abnormalities impact the networks and pathways of the dynamic pain connectome. Overall, functional and structural neuroimaging have the potential to identify predictive biomarkers that can be used to guide development of personalized pain management of neuropathic pain.