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SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu
Alexandra Tabachnikova1, Akiko Iwasaki2
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.
Trends in Immunology
|November 23, 2024
Abstract
None:
Innate immune cells that are epigenetically reprogrammed by infection can modify host responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming of murine airway-resident macrophages following recovery from SARS-CoV-2 infection, conferring protection from pathology and lethality following secondary influenza A virus (IAV) challenge without reducing viral titers.

