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Updated: Jun 6, 2025

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
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High-affinity agonists reveal recognition motifs for the MRGPRD GPCR

Chunyu Wang1, Yongfeng Liu2, Marion Lanier3

  • 1Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Insitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.

Cell Reports
|November 24, 2024
PubMed
Summary

Researchers discovered potent new agonists for the understudied human MRGPRD protein, crucial for sensing pain and itch. These findings, including structural insights, pave the way for better understanding and drug design for this receptor.

Keywords:
CP: Molecular biologyGPCRMRGPRDagonist recognitiondrug discoverystructure

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