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Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

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Altered structural and functional homotopic connectivity associated with cognitive changes in SLE.

Sha Ni¹, Ning An¹, Chunlei Li²

¹Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Lupus Science & Medicine

|November 24, 2024

Summary

Systemic lupus erythematosus (SLE) patients show altered brain connectivity and structure in the insula and parahippocampal gyrus. These changes correlate with cognitive deficits and lupus-specific antibodies.

Keywords:

Antibodies Autoimmune Diseases Magnetic Resonance Imaging Systemic Lupus Erythematosus

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Area of Science:

Neuroimaging
Neurology
Rheumatology

Background:

Previous research indicates functional brain changes in Systemic Lupus Erythematosus (SLE) patients.
Interhemispheric cerebral changes in SLE remain underexplored.

Purpose of the Study:

To investigate functional and structural interhemispheric changes in SLE patients using fMRI.
To correlate these brain alterations with cognitive function and clinical markers.

Main Methods:

54 SLE patients and 32 healthy controls (HCs) underwent MRI and neuropsychological tests.
Voxel-mirrored homotopic connectivity (VMHC) and grey matter volume were analyzed.
Correlation analyses examined relationships between imaging data, cognition, and biochemical markers.

Main Results:

SLE patients exhibited increased VMHC in the insula and parahippocampal gyrus compared to HCs.
Reduced grey matter volume was observed in these same regions in SLE patients.
Increased insular VMHC correlated with impaired orientation and attention; reduced grey matter correlated with attention and abstraction deficits. Both were linked to lupus antibodies.

Conclusions:

Structural and functional changes in the insula and parahippocampal gyrus may serve as neuroimaging biomarkers for SLE.
Lupus-associated antibodies might play a role in SLE-related brain dysfunction.