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Evaluating the prognostic impact of inflammatory markers on treatment outcomes in patients with intrahepatic cholangiocarcinoma undergoing radioembolization

  • 0Çukurova University Faculty of Medicine, Balcalı Hospital, Department of Radiology, Adana, Türkiye.
Radiology +

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November 25, 2024

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November 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Systemic inflammatory markers like neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) can predict treatment response in intrahepatic cholangiocarcinoma (iCCA) patients undergoing radioembolization. Lower levels of these markers correlate with better outcomes, aiding personalized treatment strategies.

Area Of Science

  • Hepatobiliary cancers
  • Oncology
  • Radiology

Background

  • Intrahepatic cholangiocarcinoma (iCCA) is an aggressive cancer with limited treatment options.
  • Radioembolization shows promise for iCCA, but patient response varies.
  • Predictive biomarkers are needed to guide radioembolization therapy for iCCA.

Purpose Of The Study

  • To evaluate the prognostic impact of systemic inflammatory response markers on radioembolization outcomes in iCCA patients.
  • To assess if neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) predict treatment response and survival.

Main Methods

  • Retrospective analysis of 70 iCCA patients treated with radioembolization.
  • Measurement of NLR, PLR, and SII from peripheral blood samples.
  • Assessment of treatment response using modified RECIST criteria and survival analysis via Kaplan-Meier and Cox regression.

Main Results

  • Lower NLR, PLR, and SII levels were associated with significantly higher objective response rates (P=0.032, P=0.016, P=0.001).
  • High NLR, PLR, and SII correlated with shorter overall survival and progression-free survival.
  • High SII, lymph node metastasis, and elevated serum total bilirubin were independent negative prognostic factors.

Conclusions

  • Systemic inflammatory markers (NLR, PLR, SII) are valuable prognostic indicators for iCCA patients undergoing radioembolization.
  • These markers can help identify patients likely to benefit from personalized treatment strategies.
  • Utilizing these inflammatory markers may improve clinical outcomes for iCCA patients.

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