The role of multiparametric magnetic resonance imaging in the differentiation of low- and high-grade non-muscle invasive bladder cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Apparent diffusion coefficient ratio (ADCtR) effectively differentiates low- and high-grade non-muscle invasive bladder cancers (NMIBC). This imaging biomarker shows promise for improved preoperative diagnosis and patient management in NMIBC cases.
Area Of Science
- Radiology
- Oncology
- Medical Imaging
Background
- Non-muscle invasive bladder cancer (NMIBC) grading is crucial for treatment stratification.
- Accurate preoperative differentiation between low- and high-grade NMIBC is essential for optimal patient management.
- Current imaging techniques have limitations in reliably distinguishing tumor grades.
Purpose Of The Study
- To assess the diagnostic performance of apparent diffusion coefficient (ADC) measurements and dynamic contrast enhancement (DCE) parameters in differentiating low- and high-grade NMIBC.
- To evaluate the utility of ADC measurements, specifically the apparent diffusion coefficient ratio (ADCtR), in preoperative grading of NMIBC.
Main Methods
- Retrospective analysis of 89 NMIBC patients (histopathologically confirmed).
- Calculation of semi-quantitative DCE parameters (WiR, WoR, TTP, PE) and ADC measurements (ADC, ADCt, ADCw, ADCtR, ADCwR).
- Receiver operating characteristic (ROC) curve analysis to determine diagnostic efficacy and inter-reader agreement assessment.
Main Results
- DCE parameters (WoR, WiR, TTP, PE) did not significantly differ between low- and high-grade NMIBC.
- ADC measurements, including ADCt, ADCw, ADCtR, and ADCwR, were significantly lower in high-grade NMIBC (P < 0.001).
- ADCtR demonstrated the highest diagnostic value (AUC 0.879-0.857) for differentiating tumor grades, with excellent inter-reader agreement for ADC measurements.
Conclusions
- Semi-quantitative DCE parameters are not effective in distinguishing low- from high-grade NMIBC.
- Apparent diffusion coefficient ratio (ADCtR) is a promising imaging biomarker for preoperative differentiation of NMIBC grades.
- ADCtR can potentially improve patient management strategies for NMIBC by providing crucial preoperative grading information.
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