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Updated: Jun 6, 2025
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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
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Frailty in kidney transplant recipients
Junji Uchida1, Tomoaki Iwai1, Yuichi Machida1
1Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Osaka Prefecture, Japan.
Summary
Kidney transplantation offers significant benefits for elderly patients, improving life expectancy and quality of life. However, frail elderly transplant recipients face increased risks of adverse outcomes, highlighting the need for careful management.
Area of Science:
- Nephrology
- Geriatrics
- Transplantation Medicine
Background:
- Kidney transplantation is the preferred treatment for elderly individuals, enhancing quality of life and survival compared to dialysis.
- Aging populations, particularly in Japan, are increasing the number of older kidney transplant recipients.
- Elderly transplant recipients on immunosuppression are more susceptible to age-related conditions like infections, dementia, and malignancies.
Purpose of the Study:
- To examine the impact of frailty on elderly kidney transplant recipients.
- To assess the risks associated with frailty in kidney transplant candidates and recipients.
- To evaluate kidney transplantation as a potential intervention for frailty in dialysis patients.
Main Methods:
- This study reviews existing literature on frailty in kidney transplant recipients.
- It analyzes age-related outcomes and complications in this population.
- The impact of frailty on wait-listed candidates and post-transplant outcomes is discussed.
Main Results:
- Frailty, characterized by reduced physiological reserve, increases vulnerability to adverse events in elderly individuals, including those with chronic kidney disease.
- Frailty is linked to higher rates of hospital readmissions, infections, dementia, malignancies, and fractures in elderly kidney transplant recipients.
- Frail candidates face increased risks of wait-list removal or death, while frailty at transplantation correlates with complications like delayed graft function and longer hospital stays.
Conclusions:
- Kidney transplantation remains a beneficial option for the elderly, but frailty presents significant risks.
- Frailty management is crucial for improving outcomes in elderly kidney transplant recipients.
- Kidney transplantation may be a viable treatment for frailty in patients on dialysis.
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