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Related Experiment Video

Updated: Jun 6, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Assessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian

Jun Wu1, Jia-Hao Xu1, Hao-Qi Zou1

  • 1Department of Epidemiology and Biostastics, School of Public Health, Shunde Women and Children's Hospital, Guangdong Medical University, Dongguan, China.

Journal of Cachexia, Sarcopenia and Muscle
|November 25, 2024
PubMed
Summary

Higher serum bilirubin levels are associated with a lower risk of frailty in White British adults. Mildly elevated bilirubin shows protective effects, particularly in women.

Keywords:
Mendelian randomizationbilirubinfrailty

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Area of Science:

  • Gerontology
  • Biochemistry
  • Epidemiology

Background:

  • Bilirubin, a haemoglobin breakdown product, is recognized for its antioxidant properties.
  • Previous studies link elevated bilirubin to reduced disease risk, but its role in frailty is unexplored.

Purpose of the Study:

  • To investigate the association between serum bilirubin levels and the risk of frailty.
  • To explore potential sex-specific effects of bilirubin on frailty.

Main Methods:

  • A large cohort study of 442,223 White British participants from the UK Biobank.
  • Analysis of total and direct bilirubin levels against frailty index using multivariable regression.
  • Mendelian randomization analysis to assess genetically predicted bilirubin levels and frailty risk.

Main Results:

  • A significant non-linear negative association was found between total bilirubin levels and frailty index.
  • Mildly elevated total bilirubin levels demonstrated protective effects against pre-frailty and frailty.
  • The protective association was more pronounced in women, with Mendelian randomization confirming a negative link between genetically predicted bilirubin and frailty risk.

Conclusions:

  • Circulating total and direct bilirubin levels are negatively associated with frailty risk in White British individuals.
  • Mildly elevated total bilirubin levels offer a protective benefit against frailty, especially in women.